Scientists untangle the biology of an 'undruggable' cancer gene

Scientists have made a breakthrough in understanding the biology of the cancer gene KRAS, which has been considered 'undruggable' due to its complex structure. The gene is responsible for approximately 25% of human cancers, and its mutations are often associated with resistance to cancer therapy. Researchers at the University of California, San Diego, have identified a specific binding pocket on the KRAS protein that can be targeted by a small molecule inhibitor. This discovery could potentially lead to the development of new cancer therapies. The study was published in the journal Molecular Cell.